Earlier Statins?

Eradicating Atherosclerosis: Should We Start Statins at Younger Ages and at Lower LDL-Cs

Authors: O’Toole, Thomas; Kelsey, Michelle D.; Shah, Nishant P.; McGarrah, Robert W.; Pagidipati, Neha J.

Abstract: Given the increasing burden of cardiovascular disease, we review the literature for earlier initiation of statin therapy at younger ages and lower low-density lipoprotein cholesterol (LDL-C) levels, with the goal of preventing the development of atherosclerosis prior to clinical events. There is a rising prevalence of dyslipidemia among younger adults. Although guidelines offer recommendations for adults over 40, there is little guidance for the management of younger adults with moderately elevated LDL-C levels. Earlier and more aggressive statin use may slow progression, or even halt atherosclerosis, and may likewise be beneficial and cost-effective on a population level. Further research is needed to define the exact age and LDL-C level at which to start statin therapy. Until then, more detailed risk stratification with lab testing and imaging should be used to identify younger adults at the highest risk.

Pmid: 36006590

Doi: 10.1007/s11886-022-01760-y

Full article link here.